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PharmacoGx: An R package for analysis of large pharmacogenomic datasets

TitlePharmacoGx: An R package for analysis of large pharmacogenomic datasets
Publication TypeJournal Article
Year of Publication2015
AuthorsSmirnov, P, Safikhani, Z, El-Hachem, N, Wang, D, She, A, Olsen, C, Freeman, M, Selby, H, Gendoo, DMA, Grossman, P, Beck, AH, Aerts, HJWL, Lupien, M, Goldenberg, A, Haibe-Kains, B
JournalBioinformatics
Abstract

Summary: Pharmacogenomics holds great promise for the development of biomarkers of drug response and the design of new therapeutic options, which are key challenges in precision medicine. However such data are scattered and lack standards for efficient access and analysis, consequently preventing the realization of the full potential of pharmacogenomics. To address these issues, we implemented PharmacoGx, an easy-to-use, open source package for integrative analysis of multiple pharmacogenomic datasets. We demonstrate the utility of our package in comparing large drug sensitivity datasets, such as the Genomics of Drug Sensitivity in Cance and the Cancer Cell Line Encyclopedia. Moreover, we show how to use our package to easily perform Connectivity Map analysis. With increasing availability of drug-related data, our package will open new avenues of research for meta-analysis of pharmacogenomic data.Availability and implementation: PharmacoGx is implemented in R and can be easily installed on any system. The package is available from CRAN and its source code is available from GitHub.Contact: bhaibeka@uhnresearch.caSupplementary Information: Supplementary data are available at Bioinformatics online.

URLhttp://bioinformatics.oxfordjournals.org/content/early/2015/12/09/bioinformatics.btv723.abstract
DOI10.1093/bioinformatics/btv723

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