Complete List of Works

Defrance, Matthieu; Touzet, Hélène

Predicting transcription factor binding sites using local over-representation and comparative genomics. Journal Article

In: BMC bioinformatics, vol. 7, pp. 396, 2006, (DOI: 10.1186/1471-2105-7-396).

Santos, Francisco C; Pacheco, Jorge J M; Lenaerts, Tom

Cooperation prevails when individuals adjust their social ties. Journal Article

In: PLoS computational biology, vol. 2, no. 10, pp. e140, 2006, (DOI: 10.1371/journal.pcbi.0020140).

@article{info:hdl:2013/69853,

title = {Cooperation prevails when individuals adjust their social ties.},

author = {Francisco C Santos and Jorge J M Pacheco and Tom Lenaerts},

url = {https://dipot.ulb.ac.be/dspace/bitstream/2013/69853/3/doi_46963.pdf},

year  = {2006},

date = {2006-01-01},

journal = {PLoS computational biology},

volume = {2},

number = {10},

pages = {e140},

abstract = {Conventional evolutionary game theory predicts that natural selection favours the selfish and strong even though cooperative interactions thrive at all levels of organization in living systems. Recent investigations demonstrated that a limiting factor for the evolution of cooperative interactions is the way in which they are organized, cooperators becoming evolutionarily competitive whenever individuals are constrained to interact with few others along the edges of networks with low average connectivity. Despite this insight, the conundrum of cooperation remains since recent empirical data shows that real networks exhibit typically high average connectivity and associated single-to-broad-scale heterogeneity. Here, a computational model is constructed in which individuals are able to self-organize both their strategy and their social ties throughout evolution, based exclusively on their self-interest. We show that the entangled evolution of individual strategy and network structure constitutes a key mechanism for the sustainability of cooperation in social networks. For a given average connectivity of the population, there is a critical value for the ratio W between the time scales associated with the evolution of strategy and of structure above which cooperators wipe out defectors. Moreover, the emerging social networks exhibit an overall heterogeneity that accounts very well for the diversity of patterns recently found in acquired data on social networks. Finally, heterogeneity is found to become maximal when W reaches its critical value. These results show that simple topological dynamics reflecting the individual capacity for self-organization of social ties can produce realistic networks of high average connectivity with associated single-to-broad-scale heterogeneity. On the other hand, they show that cooperation cannot evolve as a result of "social viscosity" alone in heterogeneous networks with high average connectivity, requiring the additional mechanism of topological co-evolution to ensure the survival of cooperative behaviour. copyright 2006 Santos et al.},

note = {DOI: 10.1371/journal.pcbi.0020140},

keywords = {},

pubstate = {published},

tppubtype = {article}

}

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Conventional evolutionary game theory predicts that natural selection favours the selfish and strong even though cooperative interactions thrive at all levels of organization in living systems. Recent investigations demonstrated that a limiting factor for the evolution of cooperative interactions is the way in which they are organized, cooperators becoming evolutionarily competitive whenever individuals are constrained to interact with few others along the edges of networks with low average connectivity. Despite this insight, the conundrum of cooperation remains since recent empirical data shows that real networks exhibit typically high average connectivity and associated single-to-broad-scale heterogeneity. Here, a computational model is constructed in which individuals are able to self-organize both their strategy and their social ties throughout evolution, based exclusively on their self-interest. We show that the entangled evolution of individual strategy and network structure constitutes a key mechanism for the sustainability of cooperation in social networks. For a given average connectivity of the population, there is a critical value for the ratio W between the time scales associated with the evolution of strategy and of structure above which cooperators wipe out defectors. Moreover, the emerging social networks exhibit an overall heterogeneity that accounts very well for the diversity of patterns recently found in acquired data on social networks. Finally, heterogeneity is found to become maximal when W reaches its critical value. These results show that simple topological dynamics reflecting the individual capacity for self-organization of social ties can produce realistic networks of high average connectivity with associated single-to-broad-scale heterogeneity. On the other hand, they show that cooperation cannot evolve as a result of “social viscosity” alone in heterogeneous networks with high average connectivity, requiring the additional mechanism of topological co-evolution to ensure the survival of cooperative behaviour. copyright 2006 Santos et al.

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Haibe-Kains, Benjamin; Loi, Sherene; Desmedt, Christine; Lallemand, Franccoise; Tutt, Andrew M; Gillet, Céline; Ellis, P.; Ryder, Kenneth; Harris, Adrian; Bergh, Jonas; Larsimont, Denis; Buyse, Marc; Bontempi, Gianluca; Piccart-Gebhart, Martine; Sotiriou, Christos

Gene Expression Analaysis of Tamoxifen Resistance in Breast Cancer Miscellaneous

2006, (Conference: Computational Learning and Intelligence, research Contact Day (25 September 2006: Vrussels, Belgium)).

2006

2005

2004